Acute exertional compartment syndrome of the superficial posterior compartment of the leg secondary to minor soft tissue injury is rare. This case series highlights the risk of misdiagnosis as deep venous thrombosis, followed by inadvertent anticoagulation. The delay in management did fortunately not lead to catastrophic consequences. Clinicians must not dismiss the possibility of an acute exertional compartment syndrome in the absence of direct trauma or after minor closed soft tissue injury.