Risk of iron overload in carriers of genetic mutations associated with hereditary haemochromatosis: UK Food Standards Agency workshop

Mamta Singh; Margaret Ashwell; Peter Sanderson; Janet Cade; Jennifer Moreton; Susan Fairweather-Tait; Mark Roe; Joannes J M Marx; Mark Worwood; James D Cook

Risk of iron overload in carriers of genetic mutations associated with hereditary haemochromatosis: UK Food Standards Agency workshop

Br J Nutr. 2006 Oct;96(4):770-3.

Authors

Mamta Singh¹, Margaret Ashwell, Peter Sanderson, Janet Cade, Jennifer Moreton, Susan Fairweather-Tait, Mark Roe, Joannes J M Marx, Mark Worwood, James D Cook

Affiliation

¹ Food Standards Agency, Aviation House, London WC2B 6NH, UK. [email protected]

PMID: 17010238

Abstract

The UK Food Standards Agency convened a group of expert scientists to review current research investigating diet and carriers of genetic mutations associated with hereditary haemochromatosis. The workshop concluded that individuals who are heterozygous for the C282Y mutation of the HFE gene do not appear to respond abnormally to dietary Fe and therefore do not need to change their diet to prevent accumulation of body Fe.

Publication types

Consensus Development Conference

MeSH terms

Atherosclerosis / etiology
Diet
Genetic Predisposition to Disease
Hemochromatosis / genetics
Hemochromatosis Protein
Heterozygote*
Histocompatibility Antigens Class I / genetics
Humans
Iron Overload / complications
Iron Overload / genetics*
Iron, Dietary / pharmacokinetics
Membrane Proteins / genetics
Mutation*

Substances

HFE protein, human
Hemochromatosis Protein
Histocompatibility Antigens Class I
Iron, Dietary
Membrane Proteins