Common epitope on urinary antigen derived from different Legionella pneumophila serogroup 1 strains recognized by a monoclonal antibody

Zentralbl Bakteriol. 1990 Sep;273(4):478-80. doi: 10.1016/s0934-8840(11)80455-x.

Abstract

Guinea pigs were infected intraperitoneally with 4 subgroup reference strains (Knoxville 1, Philadelphia 1, Bellingham 1, OLDA) and 2 clinical isolates of Legionella pneumophila serogroup 1. Antigenuria was demonstrated by the enzyme-linked immunosorbent assay using polyclonal antibodies and monoclonal antibody (mab) F8/5. Mab F8/5 recognizes a hitherto undetected common epitope on urinary antigen of the investigated strains.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal / immunology*
  • Antigens, Bacterial / urine*
  • Enzyme-Linked Immunosorbent Assay
  • Epitopes / urine
  • Guinea Pigs
  • Legionella / classification
  • Legionella / immunology*
  • Serotyping

Substances

  • Antibodies, Monoclonal
  • Antigens, Bacterial
  • Epitopes