Contingency awareness and fear inhibition in a human fear-potentiated startle paradigm

Behav Neurosci. 2006 Oct;120(5):995-1004. doi: 10.1037/0735-7044.120.5.995.

Abstract

Fear-potentiated startle is defined as an increase in the magnitude of the startle reflex in the presence of a stimulus that was previously paired with an aversive event. It has been proposed that a subject's awareness of the contingencies in the experiment may affect fear-potentiated startle. The authors adapted a conditional discrimination procedure (AX+/BX-), previously validated in animals, to a human fear-potentiated startle paradigm in 50 healthy volunteers. This paradigm allows for an assessment of fear-potentiated startle during threat conditions as well as inhibition of fear-potentiated startle during safety conditions. A response keypad was used to assess contingency awareness on a trial-by-trial basis. Both aware and unaware subjects showed fear-potentiated startle. However, awareness was related to stimulus discrimination and fear inhibition.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acoustic Stimulation
  • Adult
  • Aged
  • Arousal
  • Association Learning*
  • Attention
  • Awareness*
  • Blinking*
  • Conditioning, Classical*
  • Cues
  • Electromyography
  • Fear*
  • Female
  • Humans
  • Inhibition, Psychological*
  • Male
  • Middle Aged
  • Photic Stimulation
  • Psychomotor Performance
  • Reflex, Startle*