Abstract
The mutation status of genes encoding the variable region of immunoglobulin heavy chains (IgV(H)) is a strong predictor of disease progression and survival in B-cell chronic lymphocytic leukemia (B-CLL). We investigated whether there is an association between the concentration of both vascular endothelial growth factor and basic fibroblast growth factor and IgV(H) mutation status in 49 untreated B-CLL patients.
Publication types
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Comparative Study
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Fibroblast Growth Factor 2 / blood*
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Fibroblast Growth Factor 2 / genetics
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Humans
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Immunoglobulin Heavy Chains / genetics*
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Immunoglobulin Variable Region / genetics*
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Leukemia, Lymphocytic, Chronic, B-Cell / blood*
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Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
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Middle Aged
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Somatic Hypermutation, Immunoglobulin / genetics
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Vascular Endothelial Growth Factor A / blood*
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Vascular Endothelial Growth Factor A / genetics
Substances
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Immunoglobulin Heavy Chains
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Immunoglobulin Variable Region
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Vascular Endothelial Growth Factor A
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Fibroblast Growth Factor 2