Treatment failure of nosocomial pertussis infection in a very-low-birth-weight neonate

Stéphane Bonacorsi; Caroline Farnoux; Philippe Bidet; Valérie Caro; Sophie Aizenfisz; Mounir Benhayoun; Yannick Aujard; Nicole Guiso; Edouard Bingen

doi:10.1128/JCM.01062-06

Treatment failure of nosocomial pertussis infection in a very-low-birth-weight neonate

J Clin Microbiol. 2006 Oct;44(10):3830-2. doi: 10.1128/JCM.01062-06.

Authors

Stéphane Bonacorsi¹, Caroline Farnoux, Philippe Bidet, Valérie Caro, Sophie Aizenfisz, Mounir Benhayoun, Yannick Aujard, Nicole Guiso, Edouard Bingen

Affiliation

¹ Laboratoire d'Etudes de Génétique Bactérienne dans les Infections de l'Enfant (EA 3105), Université Denis Diderot-Paris 7, Service de Microbiologie, Paris, France.

Abstract

We describe a case of nosocomial maternal transmission of Bordetella pertussis to a very-low-birth-weight (VLBW) neonate in whom treatment was unsuccessful. This case underscores the need for rapid and sensitive PCR diagnosis in VLBW neonates and in parents with clinical signs of pertussis and suggests that standard treatment may not be appropriate for VLBW neonates.

Publication types

Case Reports

MeSH terms

Anti-Bacterial Agents / therapeutic use*
Azithromycin / therapeutic use
Cross Infection / drug therapy*
Diphtheria-Tetanus-acellular Pertussis Vaccines / immunology
Humans
Infant, Newborn
Infant, Very Low Birth Weight
Josamycin / therapeutic use*
Male
Treatment Failure
Trimethoprim, Sulfamethoxazole Drug Combination / therapeutic use
Whooping Cough / drug therapy*
Whooping Cough / prevention & control

Substances

Anti-Bacterial Agents
Diphtheria-Tetanus-acellular Pertussis Vaccines
Trimethoprim, Sulfamethoxazole Drug Combination
Azithromycin
Josamycin