[A hepatocellular carcinoma showing sarcomatous features and an extensive metastasis]

Gan No Rinsho. 1990 Dec;36(15):2587-93.
[Article in Japanese]

Abstract

A 47-year-old female was admitted for a right hypochondrial pain and was diagnosed as having a hepatic tumor with a cystic lesion. After a right and a caudal lobectomy, she died of hepatic failure due to a tumoral recurrence. At autopsy, a cystic tumoral nodule, 15 x 7 cm in size, and numerous other nodules were revealed in the liver. Metastases were seen in both lungs, the left kidney, the colon, the mesenterium, the peritoneum, the diaphragm, and the para-pancreatic lymph nodes. The hepatic tumors consisted of four types of tumor cells: spindle, round, mixed (spindle and round cells), and cells with pseudoalveolar features. All tumor cells showed a positive immunohistochemical reaction to polyclonal keratin, low molecular monoclonal keratin, alpha 1 anti-trypsin, vimentin and to actin in their cytoplasms. This is considered a very rare case.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Actins / analysis
  • Biomarkers, Tumor / analysis
  • Carcinoma, Hepatocellular / diagnosis
  • Carcinoma, Hepatocellular / pathology*
  • Female
  • Humans
  • Immunohistochemistry
  • Keratins / analysis
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / pathology*
  • Middle Aged
  • Neoplasm Metastasis
  • Sarcoma / diagnosis
  • Sarcoma / pathology*
  • Vimentin / analysis
  • alpha 1-Antitrypsin / analysis

Substances

  • Actins
  • Biomarkers, Tumor
  • Vimentin
  • alpha 1-Antitrypsin
  • Keratins