Abstract
A series of 7-hydroxy-4-oxo-4H-chromene- (3a - h) and 7-hydroxychroman-2-carboxylic acid N-alkyl amides (4a - g) were synthesized and their antioxidant activities were evaluated. While compounds 3a - h were less active, compounds 4a - g exhibited more potent inhibition of lipid peroxidation initiated by Fe2+ and ascorbic acid in rat brain homogenates. Among them, 7-hydroxychroman-2-carboxylic acid N-alkylamides (4e - g) bearing nonyl, decyl, and undecyl side chain exhibited 3 times more potent inhibition than trolox (1).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkanes / chemical synthesis*
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Alkanes / pharmacology*
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Animals
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Antioxidants / chemical synthesis*
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Antioxidants / pharmacology*
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Ascorbic Acid / pharmacology
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Biphenyl Compounds
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Chromans / chemical synthesis*
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Chromans / pharmacology*
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Free Radical Scavengers / chemical synthesis
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Free Radical Scavengers / pharmacology
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Indicators and Reagents
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Iron / pharmacology
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Lipid Peroxidation / drug effects
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Picrates / chemistry
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Rats
Substances
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Alkanes
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Antioxidants
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Biphenyl Compounds
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Chromans
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Free Radical Scavengers
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Indicators and Reagents
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Picrates
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1,1-diphenyl-2-picrylhydrazyl
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Iron
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Ascorbic Acid
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6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid