Human urinary trypsin inhibitor bolus infusion improved severe interstitial pneumonia in mixed connective tissue disease

Shizuyo Tsujimura; Kazuyoshi Saito; Shingo Nakayamada; Yoshiya Tanaka

doi:10.1007/s10165-005-0421-y

Human urinary trypsin inhibitor bolus infusion improved severe interstitial pneumonia in mixed connective tissue disease

Mod Rheumatol. 2005;15(5):374-80. doi: 10.1007/s10165-005-0421-y.

Authors

Shizuyo Tsujimura¹, Kazuyoshi Saito, Shingo Nakayamada, Yoshiya Tanaka

Affiliation

¹ First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu, 807-8555, Japan.

PMID: 17029098
DOI: 10.1007/s10165-005-0421-y

Abstract

Interstitial pneumonia (IP) with mixed connective tissue disease (MCTD) often progresses despite immunosuppressive therapies that caused serious infections. Human urinary trypsin inhibitor (UT) inhibits inflammatory factors associated with IP, without immunosuppression. UT bolus infusion rescued a female MCTD patient with refractory IP and severe opportunistic fungal pneumonia. Her IP diminished with monthly UT bolus infusion despite tapering of prednisolone, without UT-related side effects. UT pulse therapy could prove beneficial for refractory IP in MTCD even with opportunistic infections.