Abstract
The effect of FK506 and cyclosporine on NK and ADCC activity was evaluated. Cytotoxic cells mediating both activities are resistant to FK506. In contrast, preincubation of ADCC and NK effectors with cyclosporine decreases their cytotoxic potential, while adding the drug to the assays is without effect.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Antibody-Dependent Cell Cytotoxicity / drug effects*
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Cyclosporins / pharmacology*
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Humans
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Immunosuppressive Agents / pharmacology*
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Killer Cells, Natural / drug effects*
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Killer Cells, Natural / immunology
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Tacrolimus
Substances
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Anti-Bacterial Agents
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Cyclosporins
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Immunosuppressive Agents
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Tacrolimus