Rhodium-catalysed addition of organotrialkoxysilanes to alpha-substituted acrylic esters

Org Biomol Chem. 2006 Sep 7;4(17):3235-41. doi: 10.1039/b606977k. Epub 2006 Jul 26.

Abstract

The cationic rhodium complex [Rh(cod)2][BF4] effectively catalyses the 1,4-addition of organotrialkoxysilanes to alpha-substituted acrylic esters. The reactions are promoted by heating in an oil-bath or more conveniently in a microwave reactor allowing rapid access to a useful range of functionalised products including 2-alkyl succinates and alpha-amino acid derivatives.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Esters / chemistry*
  • Magnetic Resonance Spectroscopy
  • Metals
  • Models, Molecular
  • Molecular Conformation
  • Naphthalimides / chemistry
  • Organic Chemicals / chemical synthesis*
  • Rhodium*
  • Silanes / chemistry*

Substances

  • Esters
  • Metals
  • Naphthalimides
  • Organic Chemicals
  • Silanes
  • Rhodium