[Effects of acupuncture on expressions of transcription factors NF-E2, YB-1, LRG47 in the SAMP10 mouse]

Zhongguo Zhen Jiu. 2006 Sep;26(9):651-4.
[Article in Chinese]

Abstract

Objective: To explore the mechanism of acupuncture in delaying aging.

Methods: Using SAMP10 mice and normal control SAMR1 as model and applying RT-PCR and DIG probed Northern blot techniques to observe expression of NF-E2, YB-1, LRG47 genes in whole brain, cortex and hippocampus in the 8-month SAMR1 control group, 8-month SAMP10 control group, 8-month SAMP10 acupuncture group and 8-month SAMP10 non-point acupuncture group.

Results: In the SAMP10 control group, the expression of NF-E2, YB-1 and LRG47 were down-regulated in the whole brain, cortex and hippocampus, and after acupuncture they were up-regulated and tended to normal.

Conclusion: Aging of the SAMP10 mouse brain is related with expression of NF-E2, YB-1 and LRG47 genes, and acupuncture can regulate the expression of NF-E2, YB-1 and LRG47 genes, improving the functions of erythrocyte series, increasing proliferation of cells and immune function of cells in anti-bacteria, hence anti-aging.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acupuncture Therapy*
  • Aging / metabolism*
  • Animals
  • Brain / metabolism
  • Female
  • GTP-Binding Proteins / genetics*
  • Gene Expression Regulation*
  • Male
  • Mice
  • NF-E2 Transcription Factor, p45 Subunit / genetics*
  • RNA, Messenger / analysis
  • Y-Box-Binding Protein 1 / genetics*

Substances

  • Ifi1 protein, mouse
  • NF-E2 Transcription Factor, p45 Subunit
  • Nfe2 protein, mouse
  • RNA, Messenger
  • Y-Box-Binding Protein 1
  • GTP-Binding Proteins