The objective of the present study was to investigate the effect of beta2-adrenoreceptor polymorphisms Arg16Gly and Gln27Glu as well as their relationship to the pulmonary function parameters, and the clinical presentation in patients with asthma and allergic rhinitis. Investigated polymorphisms were in linkage disequilibrium, therefore their effects should be evaluated collectively. Although no significant association could be found with the presence of asthma or allergic rhinitis in studied population, polymorphisms of beta2-adrenoreceptor can influence pulmonary function in these patients. These effects significantly differ between men and women, possibly indicating the effect of sex hormones on genetic regulation of pulmonary function.