The downregulation of asparagine synthetase expression can increase the sensitivity of cells resistant to l-asparaginase

Leukemia. 2006 Dec;20(12):2199-201. doi: 10.1038/sj.leu.2404423. Epub 2006 Oct 12.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Monoclonal / pharmacology
  • Apoptosis / drug effects
  • Asparaginase / pharmacology*
  • Aspartate-Ammonia Ligase / antagonists & inhibitors*
  • Aspartate-Ammonia Ligase / genetics
  • Aspartate-Ammonia Ligase / physiology
  • Drug Resistance
  • Humans
  • Mice
  • Mice, Inbred BALB C
  • RNA Interference

Substances

  • Antibodies, Monoclonal
  • Asparaginase
  • Aspartate-Ammonia Ligase