Abstract
In a community follow-up conducted in the Central Highlands of Madagascar, the cellular responses to synthetic peptides from the immunodominant regions of Pf155/RESA and the repeat region of the circumsporozoite protein were studied. Seasonal variations of the T cell response were measured at the individual level; the relationship between this response and the presence of parasites in blood was assessed; the question of the possible protective value of the lymphocyte proliferation in presence of a specific antigen was addressed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Amino Acid Sequence
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Animals
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Antigens, Protozoan / immunology*
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Antigens, Surface / immunology*
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Child
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Epitopes / immunology
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Humans
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Immunity, Cellular
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Longitudinal Studies
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Madagascar
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Malaria / blood
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Malaria / immunology
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Malaria / parasitology
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Middle Aged
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Molecular Sequence Data
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Peptide Fragments / chemical synthesis
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Peptide Fragments / immunology
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Plasmodium falciparum / immunology*
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Protozoan Proteins / immunology*
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Seasons
Substances
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Antigens, Protozoan
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Antigens, Surface
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Epitopes
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Peptide Fragments
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Protozoan Proteins
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circumsporozoite protein, Protozoan
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ring-infected erythrocyte surface antigen (RESA), Plasmodium falciparum