Complanadines C and D, new dimeric alkaloids from Lycopodium complanatum

Kan'ichiro Ishiuchi; Takaaki Kubota; Yuzuru Mikami; Yutaro Obara; Norimichi Nakahata; Jun'ichi Kobayashi

doi:10.1016/j.bmc.2006.09.043

Complanadines C and D, new dimeric alkaloids from Lycopodium complanatum

Bioorg Med Chem. 2007 Jan 1;15(1):413-7. doi: 10.1016/j.bmc.2006.09.043. Epub 2006 Oct 12.

Authors

Kan'ichiro Ishiuchi¹, Takaaki Kubota, Yuzuru Mikami, Yutaro Obara, Norimichi Nakahata, Jun'ichi Kobayashi

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

PMID: 17046268
DOI: 10.1016/j.bmc.2006.09.043

Abstract

Two new dimeric Lycopodium alkaloids, complanadines C (1) and D (2), have been isolated from the club moss Lycopodium complanatum, and the structures and relative stereochemistry of 1 and 2 were elucidated on the basis of the spectral data. Complanadine D (2) enhanced mRNA expression for NGF.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry*
Alkaloids / isolation & purification
Dimerization
Heterocyclic Compounds, 4 or More Rings / chemistry*
Heterocyclic Compounds, 4 or More Rings / isolation & purification*
Lycopodium / chemistry*
Magnetic Resonance Spectroscopy / methods
Magnetic Resonance Spectroscopy / standards
Models, Molecular
Molecular Conformation
Reference Standards
Stereoisomerism

Substances

Alkaloids
Heterocyclic Compounds, 4 or More Rings
complanadine C
complanadine D