Insights into recombination from population genetic variation

Curr Opin Genet Dev. 2006 Dec;16(6):565-72. doi: 10.1016/j.gde.2006.10.001. Epub 2006 Oct 16.

Abstract

Patterns of genetic variation in natural populations are shaped by, and hence carry valuable information about, the underlying recombination process. In the past five years, the increasing availability of large-scale population genetic data on dense sets of markers, coupled with advances in statistical methods for extracting information from these data, have led to several important advances in our understanding of the recombination process in humans. These advances include the identification of large numbers of 'hotspots', where recombination appears to take place considerably more frequently than in the surrounding sequence, and the identification of DNA sequence motifs that are associated with the locations of these hotspots.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Crossing Over, Genetic
  • Databases, Genetic
  • Evolution, Molecular*
  • Genetic Variation*
  • Genetics, Population
  • Humans
  • Population / genetics*
  • Recombination, Genetic*