[Prediction of the possible tertiary structure alterations of p53 protein following point mutation in p53 gene condon 282 in lung cancer cells]

Chang-hu Du; Jun Xu; Nan-shan Zhong

[Prediction of the possible tertiary structure alterations of p53 protein following point mutation in p53 gene condon 282 in lung cancer cells]

Nan Fang Yi Ke Da Xue Xue Bao. 2006 Oct;26(10):1458-9.

[Article in Chinese]

Authors

Chang-hu Du¹, Jun Xu, Nan-shan Zhong

Affiliation

¹ Guangzhou Respiratory Disease Institute, Guangzhou Medical College, Guangzhou 510120, China. [email protected]

PMID: 17062352

Abstract

This study was carried out to predict the possible tertiary structure alterations of p53 protein after point mutation of p53 gene condon 282 in lung cancer cells based on the latest 3D structure analysis platform series of Phyre software. It was found that the p53 gene condon 282 mutation (Arg/Leu) may destabilize the H2 helix and DNA binding in the major groove by compromising the contacts of p53 protein with the beta-hairpin of DNA binding surface.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Base Sequence
Codon / genetics
Humans
Lung Neoplasms / genetics
Lung Neoplasms / pathology
Models, Molecular
Molecular Sequence Data
Point Mutation*
Protein Structure, Tertiary
Tumor Suppressor Protein p53 / chemistry
Tumor Suppressor Protein p53 / genetics*

Substances

Codon
Tumor Suppressor Protein p53