Abstract
The 3-aminoquinzolinediones represent a new series of antibacterial agents structurally related to the fluoroquinolones. They are inhibitors of bacterial gyrase and topoisomerase IV and demonstrate clinically useful antibacterial activity against fastidious Gram-negative and Gram-positive organisms, including multidrug- and fluoroquinolone-resistant organisms. These agents also demonstrate in vivo efficacy in murine systemic infection models.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology*
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Bacteria / drug effects*
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DNA Topoisomerase IV / antagonists & inhibitors
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Drug Resistance, Multiple, Bacterial / drug effects
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / pharmacology
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Gram-Negative Bacteria / drug effects
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Gram-Positive Bacteria / drug effects
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Methicillin Resistance
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Microbial Sensitivity Tests
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Quinazolinones / chemical synthesis*
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Structure-Activity Relationship
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Topoisomerase II Inhibitors
Substances
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Anti-Bacterial Agents
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Enzyme Inhibitors
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Quinazolinones
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Topoisomerase II Inhibitors
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DNA Topoisomerase IV