Abstract
Two new guaianolides, named chinensiolides D (5) and E (6), were isolated from Ixeris chinensis Nakai, and their structures were determined to be 10alpha-hydroxy-3-oxoguaia-11(13)-eno-12,6alpha-lactone (5) and 10alpha-hydroxy-3beta-O-[2,6-di(p-hydroxyphenylacetyl)-beta-glucopylanosyl]guaia-4(15),11(13)-dieno-12,6alpha-lactone (6). The first isolation of (11S)-10alpha-hydroxy-3-oxoguaia-4-eno-12,6alpha-lactone (4) from natural sources and its characterization are also reported. Chinenciolide E (6) showed significant growth inhibitory activity toward VA-13 malignant lung tumor cells (IC50 = 0.72 microM).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic* / chemistry
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Antineoplastic Agents, Phytogenic* / isolation & purification
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Antineoplastic Agents, Phytogenic* / pharmacology
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Asteraceae / chemistry*
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal* / chemistry
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Drugs, Chinese Herbal* / isolation & purification
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Drugs, Chinese Herbal* / pharmacology
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Humans
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Inhibitory Concentration 50
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Intercellular Adhesion Molecule-1 / biosynthesis
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Intercellular Adhesion Molecule-1 / drug effects
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Molecular Structure
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Plants, Medicinal / chemistry*
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Sesquiterpenes, Guaiane* / chemistry
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Sesquiterpenes, Guaiane* / isolation & purification
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Sesquiterpenes, Guaiane* / pharmacology
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Sesquiterpenes, Guaiane
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chinensiolide D
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chinensiolide E
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Intercellular Adhesion Molecule-1