Successful treatment of Candida krusei fungemia with amphotericin B and caspofungin

Med Mycol. 2006 Nov;44(7):655-7. doi: 10.1080/13693780600686929.

Abstract

We report a leukemic patient with C. krusei fungemia who failed to respond to liposomal amphotericin B therapy alone. The addition of caspofungin eradicated infection and was well tolerated. Our report is the first to describe successful treatment of a patient with invasive C. krusei infection using this combination of antifungals. Combination therapy could be a useful treatment option for invasive candidosis, particularly when caused by more resistant species such as C. krusei.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amphotericin B / pharmacology
  • Amphotericin B / therapeutic use*
  • Candida / drug effects
  • Candida / isolation & purification
  • Candidiasis / drug therapy*
  • Candidiasis / microbiology
  • Caspofungin
  • Drug Therapy, Combination
  • Echinocandins
  • Fungemia / drug therapy*
  • Humans
  • Leukemia / complications
  • Leukemia / drug therapy
  • Lipopeptides
  • Male
  • Peptides, Cyclic / pharmacology
  • Peptides, Cyclic / therapeutic use*
  • Treatment Outcome

Substances

  • Echinocandins
  • Lipopeptides
  • Peptides, Cyclic
  • Amphotericin B
  • Caspofungin