Synthesis of plakortone B and analogs

Org Lett. 2006 Nov 9;8(23):5203-6. doi: 10.1021/ol0618656.

Abstract

[Structure: see text] Use of a palladium-mediated alkoxycarbonylation/lactonization process provides a variable route to analogs of the plakortones. Four different analogs, including natural plakortone B, have been synthesized via this route.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Catalysis
  • Lactones / chemical synthesis*
  • Lactones / metabolism
  • Molecular Structure
  • Palladium
  • Porifera / metabolism

Substances

  • Lactones
  • plakortone B
  • Palladium