Serendipitous discovery of novel imidazolopyrazole scaffold as selective androgen receptor modulators

Bioorg Med Chem Lett. 2007 Jan 15;17(2):439-43. doi: 10.1016/j.bmcl.2006.10.035. Epub 2006 Oct 17.

Abstract

A novel imidazolopyrazole derivative has been fortuitously discovered as potent selective androgen receptor modulator with in vivo efficacy.

MeSH terms

  • Animals
  • Binding, Competitive / drug effects
  • Crystallography, X-Ray
  • In Vitro Techniques
  • Indicators and Reagents
  • Ligands
  • Male
  • Models, Molecular
  • Muscle, Skeletal / drug effects
  • Orchiectomy
  • Organ Size
  • Prostate / drug effects
  • Pyrazoles / chemical synthesis*
  • Pyrazoles / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Androgen / drug effects*
  • Structure-Activity Relationship
  • Testosterone / metabolism

Substances

  • Indicators and Reagents
  • Ligands
  • Pyrazoles
  • Receptors, Androgen
  • imidazopyrazole
  • Testosterone