Abstract
A novel imidazolopyrazole derivative has been fortuitously discovered as potent selective androgen receptor modulator with in vivo efficacy.
MeSH terms
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Animals
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Binding, Competitive / drug effects
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Crystallography, X-Ray
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In Vitro Techniques
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Indicators and Reagents
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Ligands
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Male
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Models, Molecular
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Muscle, Skeletal / drug effects
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Orchiectomy
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Organ Size
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Prostate / drug effects
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Pyrazoles / chemical synthesis*
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Pyrazoles / pharmacology*
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Rats
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Rats, Sprague-Dawley
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Receptors, Androgen / drug effects*
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Structure-Activity Relationship
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Testosterone / metabolism
Substances
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Indicators and Reagents
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Ligands
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Pyrazoles
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Receptors, Androgen
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imidazopyrazole
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Testosterone