Detoxification of pertussis toxin by site-directed mutagenesis: a review of connaught strategy to develop a recombinant pertussis vaccine

Mol Immunol. 1991 Mar;28(3):235-8. doi: 10.1016/0161-5890(91)90067-t.
No abstract available

MeSH terms

  • Animals
  • Antigens, Bacterial / genetics
  • Cloning, Molecular
  • DNA Mutational Analysis
  • Epitopes
  • Mice
  • Pertussis Toxin*
  • Pertussis Vaccine / genetics*
  • Pertussis Vaccine / immunology
  • Structure-Activity Relationship
  • Vaccines, Synthetic / genetics*
  • Vaccines, Synthetic / immunology
  • Virulence Factors, Bordetella / genetics*
  • Virulence Factors, Bordetella / immunology
  • Virulence Factors, Bordetella / toxicity

Substances

  • Antigens, Bacterial
  • Epitopes
  • Pertussis Vaccine
  • Vaccines, Synthetic
  • Virulence Factors, Bordetella
  • Pertussis Toxin