Abstract
The effect of various phosphodiesterase inhibitors, and adenosine analogues on palmitate oxidation, were studied in isolated rat myocytes. Enoximone, milrinone, and dipyridamole, at a concentration of 250 microM, stimulated palmitate oxidation by 78%, 40%, and 43%, respectively. The specific A1-agonist, N6-cyclopentyladenosine, increased palmitate oxidation by 56%, at a concentration of 250 microM. Moreover, the nucleoside transport inhibitor, S-(P-Nitrobenzyl-)6-thioinosine, increased palmitate oxidation by 40%, at a concentration of 100 microM. These data suggest that the stimulation of palmitate oxidation by enoximone and adenosine analogues may be mediated via the inhibition of the uptake and/or the oxidation of glucose in myocytes.
MeSH terms
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1-Methyl-3-isobutylxanthine / pharmacology
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Adenosine / analogs & derivatives*
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Adenosine / pharmacology*
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Amrinone / pharmacology
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Animals
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Cells, Cultured
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Dipyridamole / pharmacology
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Enoximone
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Heart / drug effects
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Imidazoles / pharmacology
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Milrinone
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Myocardium / metabolism*
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Oxidation-Reduction
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Palmitic Acid
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Palmitic Acids / metabolism*
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Phosphodiesterase Inhibitors / pharmacology*
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Purinones / pharmacology
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Pyridazines / pharmacology
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Pyridones / pharmacology
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Rats
Substances
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Imidazoles
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Palmitic Acids
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Phosphodiesterase Inhibitors
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Purinones
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Pyridazines
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Pyridones
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Palmitic Acid
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Dipyridamole
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4,5-dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2H)-pyridazinone
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Enoximone
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zaprinast
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Milrinone
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Amrinone
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Adenosine
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1-Methyl-3-isobutylxanthine