Abstract
Matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF-MS) is widely used in a variety of fields because it has the characteristics of speed, ease of use, high sensitivity, and wide detectable mass range for obtaining molecular weights and for structural characterization of macromolecules. In this article we summarize recent developments in matrix additives, new matrices, and sample-pretreatment methods using off-probe or on-probe techniques or nanomaterials for MALDI-TOF-MS analysis of biological samples.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Analytic Sample Preparation Methods / instrumentation
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Analytic Sample Preparation Methods / methods*
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Analytic Sample Preparation Methods / trends
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Arginine / analogs & derivatives
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Arginine / analysis
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Nanostructures / chemistry
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Oligodeoxyribonucleotides / analysis
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Proteins / analysis
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods*
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / trends
Substances
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Oligodeoxyribonucleotides
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Proteins
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Arginine
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benzoylarginine ethyl ester