We report the long-term outcome of percutaneous coronary interventions (PCI) in 12 HIV-infected patients. Two patients died from a HIV-related infection and seven patients suffered from severe clinical and/or angiographic restenosis requiring additional interventions or causing severe angina pectoris. Only three patients remained symptom free. We conclude that HIV-infected patients should be considered as high risk group and treated routinely with drug-eluting stents.