Abstract
The 81-kDa malate synthase (MS; Rv 1837c) and the 27-kDa MPT51 (Rv 3803c) of Mycobacterium tuberculosis are immunodominant antigens recognized by serum antibodies from approximately 80% of human immunodeficiency virus-negative smear-positive tuberculosis patients from India. We now provide evidence that the use of the MS/MPT51-based serodiagnostic assay can serve as an adjunct to sputum microscopy in the rapid diagnosis of pulmonary tuberculosis.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adult
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Aged
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Antibodies, Bacterial / blood
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Antigens, Bacterial / immunology*
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Bacterial Proteins / immunology*
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Humans
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Malate Synthase / immunology*
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Middle Aged
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Mycobacterium tuberculosis / enzymology*
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Mycobacterium tuberculosis / immunology
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Mycobacterium tuberculosis / isolation & purification*
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Pilot Projects
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Tuberculosis, Pulmonary / diagnosis*
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Tuberculosis, Pulmonary / enzymology
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Tuberculosis, Pulmonary / immunology
Substances
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Antibodies, Bacterial
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Antigens, Bacterial
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Bacterial Proteins
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MPT51 protein, Mycobacterium
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Malate Synthase