Hyaline globules reacting positively with zidovudine antibody in brain and spinal cord of AIDS patients

Lancet. 1991 May 11;337(8750):1127-8. doi: 10.1016/0140-6736(91)92790-9.

Abstract

Histology of the central nervous system in nine AIDS showed extracellular hyaline globules in the white matter of the brain and the spinal cord. In immunohistochemical studies with a battery of antibodies, the only positive reaction of these globules was with an antibody to zidovudine. High-performance liquid chromatography showed the presence of a zidovudine isomer in eluates of brain tissue from these patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / drug therapy*
  • Acquired Immunodeficiency Syndrome / pathology
  • Adult
  • Antibodies / analysis*
  • Antibody Specificity
  • Brain Chemistry*
  • Extracellular Space
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Spinal Cord / chemistry*
  • Staining and Labeling
  • Zidovudine / analysis
  • Zidovudine / immunology*

Substances

  • Antibodies
  • Zidovudine