Could ATRA/Idarubicin treatment of acute promyelocytic leukemia induce the appearance of new clonal cytogenetic abnormalities in patients in complete remission?

Leuk Res. 2007 Sep;31(9):1315-7. doi: 10.1016/j.leukres.2006.10.003. Epub 2006 Nov 7.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Child
  • Chromosome Aberrations / drug effects*
  • Chromosomes, Human, Pair 20 / genetics*
  • DNA, Neoplasm / genetics
  • Female
  • Humans
  • Idarubicin / administration & dosage
  • Leukemia, Promyelocytic, Acute / drug therapy*
  • Leukemia, Promyelocytic, Acute / genetics
  • Leukemia, Promyelocytic, Acute / pathology
  • Male
  • Middle Aged
  • Remission Induction
  • Survival Rate
  • Translocation, Genetic*
  • Tretinoin / administration & dosage

Substances

  • DNA, Neoplasm
  • Tretinoin
  • Idarubicin