Thymus exclusivity: all the right conditions for T cells

Immunity. 2006 Nov;25(5):697-700. doi: 10.1016/j.immuni.2006.10.005.

Abstract

A fraction of primitive "lymphoid" precursors retain plasticity for myeloid differentiation. In this issue of Immunity, Laiosa et al. describe that Notch-Delta signals can protect thymic precursors from reprogramming into the myeloid lineage, antagonizing the enforced myeloid transcription factors such as PU.1 and C/EBPalpha.

Publication types

  • Review

MeSH terms

  • Animals
  • CCAAT-Enhancer-Binding Protein-alpha / immunology
  • CCAAT-Enhancer-Binding Protein-alpha / metabolism
  • Cell Differentiation / immunology*
  • Cell Lineage / immunology*
  • Hematopoietic Stem Cells / immunology
  • Humans
  • Proto-Oncogene Proteins / immunology
  • Proto-Oncogene Proteins / metabolism
  • Receptors, Notch / immunology
  • Receptors, Notch / metabolism
  • Receptors, Opioid, delta / immunology
  • Receptors, Opioid, delta / metabolism
  • T-Lymphocytes / cytology*
  • T-Lymphocytes / immunology*
  • Thymus Gland / cytology*
  • Thymus Gland / immunology
  • Trans-Activators / immunology
  • Trans-Activators / metabolism

Substances

  • CCAAT-Enhancer-Binding Protein-alpha
  • Proto-Oncogene Proteins
  • Receptors, Notch
  • Receptors, Opioid, delta
  • Trans-Activators
  • proto-oncogene protein Spi-1