Abstract
Protein NMR as a screening tool in drug discovery has become prominent within the past ten years. Advances in protein manipulation, whether by biological means (labeling) or physical means (NMR), have created a powerful method that is able to observe ligand-target interactions in solution.
MeSH terms
-
Chemistry, Pharmaceutical
-
Isotope Labeling / methods
-
Ligands
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular*
-
Nucleic Acids / chemistry
-
Nucleic Acids / metabolism
-
Pharmaceutical Preparations / chemistry
-
Pharmaceutical Preparations / metabolism
-
Protein Binding
-
Protein Conformation
-
Proteins / chemistry*
-
Proteins / metabolism
-
Structure-Activity Relationship
Substances
-
Ligands
-
Nucleic Acids
-
Pharmaceutical Preparations
-
Proteins