Structural determination of three new germacrane-type sesquiterpene alcohols from curdione by microbial transformation

Magn Reson Chem. 2007 Jan;45(1):90-2. doi: 10.1002/mrc.1922.

Abstract

Five germacrane-type sesquiterpene alcohols obtained from curdione (1) by microbial biotransformation were isolated. Their structures were characterized as (2R)-2beta-hydroxycurdione (2), 1alpha, 10beta-epoxy-11-hydroxycurdione (3), (2S)-2alpha, 11-dihydroxycurdione (4), 11,15-dihydroxycurdione (5) and (3R)-3alpha-hydroxycurdione (6) based on the extensive NMR studies. Among them, 4, 5 and 6 are new compounds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohols / chemistry*
  • Biotransformation
  • Magnetic Resonance Spectroscopy / methods
  • Molecular Structure
  • Mucor* / metabolism
  • Plant Structures
  • Reference Standards
  • Sesquiterpenes, Germacrane / chemistry*
  • Sesquiterpenes, Germacrane / metabolism

Substances

  • Alcohols
  • Sesquiterpenes, Germacrane
  • curdione