Abstract
Fournier's gangrene is an aggressive form of necrotizing fasciitis of the perineal, perianal or genital regions, usually caused by a polymicrobial infection that includes virulent organisms. Over the last decades, we have treated 9 patients suffering from Fournier's gangrene using systemic chemotherapy with broad-spectrum antibiotics, and with extensive, sometimes serial surgical debridement. Recently in one case, in addition to treatment, we used locally 100% oxygen in daily doses with promising results in healing wound. Herein, we report this case with a brief review of the literature concerning pathogenesis, risk factors, and treatment approaches.
MeSH terms
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Adolescent
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Anti-Bacterial Agents / administration & dosage
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Anti-Bacterial Agents / therapeutic use
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Anti-Infective Agents, Local / administration & dosage
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Anti-Infective Agents, Local / therapeutic use
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Bandages
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Debridement
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Fournier Gangrene / diagnosis
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Fournier Gangrene / drug therapy
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Fournier Gangrene / surgery
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Fournier Gangrene / therapy*
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Humans
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Male
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Metronidazole / administration & dosage
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Metronidazole / therapeutic use
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Oxygen / administration & dosage*
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Perineum* / injuries
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Perineum* / surgery
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Povidone-Iodine / administration & dosage
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Povidone-Iodine / therapeutic use
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Streptomycin / administration & dosage
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Streptomycin / therapeutic use
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Time Factors
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Treatment Outcome
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Wound Healing
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents, Local
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Metronidazole
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Povidone-Iodine
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Oxygen
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Streptomycin