The purpose of this study was to compare quality of life health identifiers in patients with and without osteoarthritis (OA) while controlling for the potentially confounding variables of gender, age, race, education, and income. Data were obtained for comparison from the Behavioral Risk Factor Surveillance System (BRFSS) database. Patients with and without OA were analyzed for differences in exercise and activity level, report of physical and mental health, and joint-related symptoms. Over 37,000 individuals were included in the analysis, 6,172 of the participants reported a diagnosis of OA. Participants with a report of OA were more likely to identify problems in all categories except report of mental health. When the potentially confounding variables were controlled, individuals with OA were more likely to report mental health problems. These findings suggest that individuals with OA are more likely to report lower levels of quality of life even while controlling confounding variables.