Abstract
A new reaction of the efficient difluorocarbene-generating reagent trimethylsilyl fluorosulfonyldifluoroacetate (TFDA) is reported in which molecules containing an N-alkylimidazole or benzimidazole structure undergo an unexpected one-pot conversion to N-difluoromethylthioureas. [reaction: see text].
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adenine / chemistry
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Benzimidazoles / chemical synthesis
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Catalysis
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Imidazoles / chemistry*
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Indicators and Reagents
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Magnetic Resonance Spectroscopy
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Spectrophotometry, Ultraviolet
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Sulfur / chemistry
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Thiourea / analogs & derivatives*
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Thiourea / chemical synthesis*
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Trimethylsilyl Compounds / chemistry*
Substances
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Benzimidazoles
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Imidazoles
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Indicators and Reagents
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Trimethylsilyl Compounds
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trimethylsilyl fluorosulfonyldifluoroacetate
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Sulfur
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Thiourea
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Adenine