Abstract
The first synthesis of sulfonamide and sulfonate analogues of a sulfated carbohydrate in which the ester oxygen of the sulfate is replaced with a CHF or CF2 group is reported. This was accomplished by electrophilic fluorination of the protected sulfonate and sulfonamide precursors. [reaction: see text].
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Bromides / chemistry
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Carbohydrates / chemical synthesis*
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Carbohydrates / chemistry
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Esters / chemistry
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Fluorides / chemical synthesis*
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Lithium Compounds / chemistry
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Magnetic Resonance Spectroscopy
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Oxygen / chemistry
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Sulfates / chemistry
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Sulfuric Acids / chemical synthesis*
Substances
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Bromides
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Carbohydrates
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Esters
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Lithium Compounds
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Sulfates
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Sulfuric Acids
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lithium bromide
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fluorosulfonic acid
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Fluorides
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Oxygen