Tolerability of beta-blockers metabolized via cytochrome P450 2D6 is sex-dependent

Clin Pharmacol Ther. 2006 Nov;80(5):551-3. doi: 10.1016/j.clpt.2006.08.004.
No abstract available

Publication types

  • Comment
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenergic beta-Antagonists / adverse effects
  • Adrenergic beta-Antagonists / metabolism*
  • Adrenergic beta-Antagonists / pharmacokinetics
  • Aged
  • Aged, 80 and over
  • Bradycardia / chemically induced
  • Cytochrome P-450 CYP2D6 / metabolism*
  • Dose-Response Relationship, Drug
  • Female
  • Germany
  • Hospitalization / statistics & numerical data
  • Humans
  • Hypotension / chemically induced
  • Longitudinal Studies
  • Male
  • Metoprolol / adverse effects
  • Metoprolol / metabolism
  • Metoprolol / pharmacokinetics
  • Middle Aged
  • Sex Factors
  • Syncope / chemically induced

Substances

  • Adrenergic beta-Antagonists
  • Cytochrome P-450 CYP2D6
  • Metoprolol