Inversion (11)(p15q22) with NUP98-DDX10 fusion gene in pediatric acute myeloid leukemia

Cristina Morerio; Maura Acquila; Annamaria Rapella; Elisa Tassano; Cristina Rosanda; Claudio Panarello

doi:10.1016/j.cancergencyto.2006.07.002

Inversion (11)(p15q22) with NUP98-DDX10 fusion gene in pediatric acute myeloid leukemia

Cancer Genet Cytogenet. 2006 Dec;171(2):122-5. doi: 10.1016/j.cancergencyto.2006.07.002.

Authors

Cristina Morerio¹, Maura Acquila, Annamaria Rapella, Elisa Tassano, Cristina Rosanda, Claudio Panarello

Affiliation

¹ Dipartimento di Ematologia ed Oncologia Pediatrica, IRCCS Istituto Giannina Gaslini, Largo G Gaslini 5, Genoa, Italy.

PMID: 17116492
DOI: 10.1016/j.cancergencyto.2006.07.002

Abstract

The inv(11)(p15q22), a rare but recurrent chromosome abnormality that creates a NUP98-DDX10 fusion gene, is associated with de novo or secondary myeloid malignancies. We report a case of acute monocytic leukemia presenting this rearrangement, studied using fluorescence in situ hybridization (FISH) and reverse transcriptase-PCR (RT-PCR). We also review the cases of inv(11) associated with NUP98-DDX10 reported in the literature.

Publication types

Case Reports
Research Support, Non-U.S. Gov't
Review

MeSH terms

Child
Chromosome Inversion*
Chromosomes, Human, Pair 11 / genetics*
DEAD-box RNA Helicases / genetics*
Gene Fusion*
Humans
Leukemia, Myeloid, Acute / drug therapy
Leukemia, Myeloid, Acute / enzymology
Leukemia, Myeloid, Acute / genetics*
Male
Molecular Sequence Data
Nuclear Pore Complex Proteins / genetics*

Substances

Nuclear Pore Complex Proteins
Nup98 protein, human
DDX10 protein, human
DEAD-box RNA Helicases

Associated data

GENBANK/AB040537
GENBANK/AB040538