Posaconazole enhances the activity of amphotericin B against Aspergillus hyphae in vitro

Antimicrob Agents Chemother. 2007 Feb;51(2):791-3. doi: 10.1128/AAC.01024-06. Epub 2006 Nov 20.

Abstract

The MICs and fractional inhibitory concentrations of posaconazole (POS) and voriconazole (VRZ), alone and in combination with amphotericin B (AMB), for the conidia and hyphae of 100 Aspergillus isolates were evaluated. POS-AMB had more synergistic activity against hyphae (75% of isolates) than VRZ-AMB (37%) and significantly more synergistic activity against hyphae than against conidia (12%).

MeSH terms

  • Amphotericin B / pharmacology*
  • Antifungal Agents / pharmacology*
  • Aspergillosis / drug therapy
  • Aspergillus / drug effects*
  • Drug Synergism
  • Drug Therapy, Combination
  • Microbial Sensitivity Tests
  • Pyrimidines / pharmacology*
  • Triazoles / pharmacology*
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • posaconazole
  • Amphotericin B
  • Voriconazole