Abstract
We assessed the pharmacokinetics and interactions of steady-state micafungin (Mycamine) or placebo with steady-state voriconazole in 35 volunteers. The 90% confidence intervals around the least-squares mean ratios for micafungin pharmacokinetic parameters and placebo-corrected voriconazole pharmacokinetic parameters were within the 80%-to-125% limits, indicating an absence of drug interaction.
Publication types
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Administration, Oral
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Adolescent
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Adult
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Antifungal Agents / administration & dosage
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Antifungal Agents / pharmacokinetics*
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Drug Administration Schedule
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Drug Interactions
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Drug Therapy, Combination
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Echinocandins
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Female
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Humans
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Lipopeptides
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Lipoproteins / administration & dosage
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Lipoproteins / pharmacokinetics*
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Male
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Micafungin
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Middle Aged
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Peptides, Cyclic / administration & dosage
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Peptides, Cyclic / pharmacokinetics*
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Pyrimidines / administration & dosage
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Pyrimidines / pharmacokinetics*
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Triazoles / administration & dosage
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Triazoles / pharmacokinetics*
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Voriconazole
Substances
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Antifungal Agents
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Echinocandins
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Lipopeptides
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Lipoproteins
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Peptides, Cyclic
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Pyrimidines
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Triazoles
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Voriconazole
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Micafungin