Abstract
Hyperimmunization with Plasmodium falciparum MSP1-42 could induce antibodies that have little or no parasite growth inhibitory activities. These antisera had no blocking activities as determined by their ability to interfere with the in vitro activities of growth inhibitory anti-MSP1-42 sera. Equally important, they enhanced the potency of growth inhibitory anti-MSP1-42 sera.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Antibodies, Blocking / biosynthesis
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Antibodies, Blocking / immunology
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Antibodies, Protozoan / biosynthesis*
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Antibodies, Protozoan / immunology*
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Enzyme-Linked Immunosorbent Assay
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Humans
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Immune Sera / immunology*
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Immunoglobulin G / biosynthesis
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Immunoglobulin G / immunology
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Merozoite Surface Protein 1 / immunology*
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Plasmodium falciparum / immunology*
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Rabbits
Substances
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Antibodies, Blocking
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Antibodies, Protozoan
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Immune Sera
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Immunoglobulin G
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Merozoite Surface Protein 1