A new monoterpene glycoside and antibacterial monoterpene glycosides from Paeonia suffruticosa

Arch Pharm Res. 2006 Oct;29(10):815-20. doi: 10.1007/BF02973899.

Abstract

Antibacterial activity-guided fractionation of the CHCI3-MeOH (1:1) extract of Paeonia suffruticosa root bark furnished three monoterpene glycosides, 6-O-vanillyoxypaeoniflorin (1), mudanpioside-H (2), and galloyl-oxypaeoniflorin (3). Of the isolated compounds, compound 1 is a new compound. All isolated compounds showed broad, but moderate, antibacterial activity with minimum inhibitory concentration (MIC) values in the range of 100 to 500 microg/mL against eighteen pathogenic microorganisms of concern for public health or zoonosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology
  • Escherichia coli / classification
  • Escherichia coli / drug effects
  • Escherichia coli / growth & development
  • Gallic Acid / analogs & derivatives
  • Gallic Acid / chemistry
  • Gallic Acid / isolation & purification
  • Gallic Acid / pharmacology
  • Glucosides / chemistry
  • Glucosides / isolation & purification
  • Glucosides / pharmacology
  • Glycosides / chemistry*
  • Glycosides / isolation & purification
  • Glycosides / pharmacology
  • Methicillin Resistance / drug effects
  • Methicillin Resistance / genetics
  • Microbial Sensitivity Tests / methods
  • Molecular Structure
  • Monoterpenes / chemistry*
  • Monoterpenes / isolation & purification
  • Monoterpenes / pharmacology
  • Paeonia / chemistry*
  • Plant Roots / chemistry
  • Salmonella enteritidis / classification
  • Salmonella enteritidis / drug effects
  • Salmonella enteritidis / growth & development
  • Shigella flexneri / drug effects
  • Shigella flexneri / growth & development
  • Staphylococcus aureus / drug effects
  • Staphylococcus aureus / genetics
  • Staphylococcus aureus / growth & development
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification
  • Triterpenes / pharmacology
  • Vibrio cholerae / drug effects
  • Vibrio cholerae / growth & development

Substances

  • 6-O-vanillyoxypaeoniflorin
  • Anti-Bacterial Agents
  • Glucosides
  • Glycosides
  • Monoterpenes
  • Triterpenes
  • mudanpinoic acid
  • mudanpioside H
  • galloyloxypaeoniflorin
  • Gallic Acid