Abstract
A series of novel 8-amino-1,3-disubstituted-imidazo[1,5-a]pyrazines was designed and synthesized as IGF-IR inhibitors.
MeSH terms
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Adenosine Triphosphate / metabolism
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Animals
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Area Under Curve
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Binding Sites
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Biological Availability
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Crystallography, X-Ray
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Databases, Protein
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Half-Life
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Imidazoles / chemical synthesis*
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Imidazoles / pharmacology*
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Indicators and Reagents
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Mice
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Models, Molecular
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Protein-Tyrosine Kinases / antagonists & inhibitors
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Pyrazines / chemical synthesis*
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Pyrazines / pharmacology*
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Receptor, IGF Type 1 / antagonists & inhibitors*
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Structure-Activity Relationship
Substances
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Imidazoles
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Indicators and Reagents
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Pyrazines
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Adenosine Triphosphate
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Protein-Tyrosine Kinases
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Receptor, IGF Type 1