Abstract
The RNA-binding protein HuR regulates the stability and translation of target mRNAs. While no HuR mutations have been found in cancer, a link between HuR and malignant transformation has been suggested in cancers of the breast, colon, lung and ovary. We describe a paradigm consistent with a central role of HuR in oncogenesis.
MeSH terms
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Animals
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Antigens, Surface / metabolism*
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Carcinoma, Non-Small-Cell Lung / metabolism
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Cell Line, Tumor
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Cell Nucleus / metabolism
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Cell Transformation, Neoplastic*
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Chromosomes, Human, Pair 19
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Colonic Neoplasms / metabolism
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Cytoplasm / metabolism
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ELAV Proteins
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ELAV-Like Protein 1
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Humans
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Mice
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Mice, Nude
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Protein Biosynthesis
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RNA Processing, Post-Transcriptional*
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RNA, Messenger / metabolism
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RNA-Binding Proteins / metabolism*
Substances
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Antigens, Surface
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ELAV Proteins
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ELAV-Like Protein 1
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ELAVL1 protein, human
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RNA, Messenger
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RNA-Binding Proteins