Abstract
Recurrent glioblastoma multiforme is a lethal disease with currently available treatment options having a limited impact on outcome. In this article, current and novel therapeutic approaches in the treatment of recurrent glioblastoma multiforme, including chemotherapy, targeted molecular agents, virotherapy/gene therapy and immunotherapy and challenges in developing novel therapeutic agents for glioblastoma multiforme will be discussed.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Angiogenesis Inhibitors / therapeutic use
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Antineoplastic Agents / therapeutic use*
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Brain Neoplasms / blood supply
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Brain Neoplasms / drug therapy*
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Brain Neoplasms / pathology
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Drug Therapy / trends
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Enzyme Inhibitors / therapeutic use
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Genetic Therapy / methods
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Glioblastoma / blood supply
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Glioblastoma / drug therapy*
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Glioblastoma / pathology
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Growth Substances / physiology
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Histone Deacetylase Inhibitors
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Humans
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Models, Biological
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Neoplasm Recurrence, Local / prevention & control*
Substances
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Angiogenesis Inhibitors
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Antineoplastic Agents
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Enzyme Inhibitors
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Growth Substances
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Histone Deacetylase Inhibitors