Abstract
Humoral and cell-mediated immune responses (CMI) were evaluated in subjects 3 and 6 years after primary and booster vaccination with either three-component acellular (Pa) or whole-cell (Pw) vaccines. Low anti-pertussis toxin (PT) antibody levels confirmed the absence of pertussis disease, consistent with ongoing protection. Anti-pertactin (PRN) antibodies, remained at higher levels in Pa-vaccinated subjects. At year 6, CMI responses continued to be present and were higher in Pa-vaccinated than Pw-vaccinated subjects. Long-term protection with Pa vaccines can be expected to be at least as good as that provided by efficacious Pw vaccines.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antibody Formation / immunology
-
Bacterial Capsules
-
Bacterial Outer Membrane Proteins / immunology
-
Bordetella pertussis / immunology*
-
Child
-
Child, Preschool
-
Diphtheria-Tetanus-Pertussis Vaccine / administration & dosage*
-
Diphtheria-Tetanus-Pertussis Vaccine / immunology*
-
Diphtheria-Tetanus-acellular Pertussis Vaccines / administration & dosage*
-
Diphtheria-Tetanus-acellular Pertussis Vaccines / immunology*
-
Haemophilus Vaccines / administration & dosage
-
Haemophilus Vaccines / immunology
-
Humans
-
Immunity, Cellular / immunology
-
Immunization, Secondary / methods*
-
Infant
-
Lymphocyte Activation / immunology
-
Lymphokines / immunology
-
Pertussis Toxin / immunology
-
Polysaccharides, Bacterial / administration & dosage
-
Polysaccharides, Bacterial / immunology
-
Virulence Factors, Bordetella / immunology
Substances
-
Bacterial Outer Membrane Proteins
-
Diphtheria-Tetanus-Pertussis Vaccine
-
Diphtheria-Tetanus-acellular Pertussis Vaccines
-
Haemophilus Vaccines
-
Haemophilus influenzae type b polysaccharide vaccine
-
Lymphokines
-
Polysaccharides, Bacterial
-
Virulence Factors, Bordetella
-
pertactin
-
Pertussis Toxin