Abstract
JC virus (JCV) is a double-stranded DNA virus belonging to family Polyomaviridae. It causes progressive multifocal leukoencephalopathy (PML), mainly in immunosuppressed people. JCV had been shown to require the serotonin 2A receptor for host cell entry. We report a case of clinical, neuroradiological and virological response of biopsy-proven PML in a 33-year-old comatose woman after treatment with the anti-psychotic drug risperidone. Since risperidone is the tightest binding of current drugs to this receptor we think this may have blocked JCV entry in our patient, allowing her immune recovery and viral clearance.
MeSH terms
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Adult
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Antiviral Agents / pharmacology
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Antiviral Agents / therapeutic use*
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Female
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Humans
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JC Virus / drug effects*
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Leukoencephalopathy, Progressive Multifocal / diagnostic imaging
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Leukoencephalopathy, Progressive Multifocal / drug therapy
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Leukoencephalopathy, Progressive Multifocal / physiopathology
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Leukoencephalopathy, Progressive Multifocal / virology*
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Magnetic Resonance Imaging
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications
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Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
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Radiography
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Risperidone / pharmacology
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Risperidone / therapeutic use*
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Stem Cell Transplantation
Substances
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Antiviral Agents
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Risperidone