Treatment with flunitrazepam of continuous spikes and waves during slow wave sleep (CSWS) in children

Seizure. 2007 Mar;16(2):190-2. doi: 10.1016/j.seizure.2006.10.013. Epub 2006 Nov 30.

Abstract

We describe our treatment of two boys with continuous spikes and waves during slow wave sleep (CSWS). One of the boys was suffering from non-convulsive status epilepticus and the other from conscious disturbance with automatism. Their ictal EEG readings showed continuous diffuse spike and wave complexes, which were considered to show electrical status. The boys were diagnosed as having CSWS, and were later diagnosed with Landau-Kleffner syndrome (LKS). EEG readings returned to normal on intravenous injection of flunitazepam (FZP) at a dose of 0.02 mg/kg, suggesting that FZP is an effective treatment for CSWS.

Publication types

  • Case Reports

MeSH terms

  • Anticonvulsants / therapeutic use*
  • Child
  • Electroencephalography / drug effects*
  • Epilepsy / pathology*
  • Flunitrazepam / therapeutic use*
  • Humans
  • Landau-Kleffner Syndrome / diagnosis*
  • Landau-Kleffner Syndrome / drug therapy
  • Male
  • Sleep / drug effects*
  • Sleep / physiology
  • Status Epilepticus / drug therapy
  • Status Epilepticus / physiopathology

Substances

  • Anticonvulsants
  • Flunitrazepam