Introduction: The most common presenting features of multiple myeloma are bone pain, anemia, renal failure or hypercalcemia. Bacterial infection as the initial presentation of this desease is rare.
Clinical case: We report the case of a 62-year-old man with pneumococcal septic arthritis of the knee revealing a multiple myeloma.
Discussion: Pneumococcal infection should lead to a suspicion of underlying illness and especially the multiple myeloma.